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Equipments > Analysis |
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Diverchim operates state-of-the-art analytical labs equipped with the best in modern instrumentation to offer open access, in discovery chemistry, process and problem solving support.
Structural analysis and quality control are the two important fields of action.
Chromatography,
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 A range of analytical scale HPLC and GC equipment as well as semi-preparative scale HPLC equipment provides the following capabilities
Reverse Phase, Normal Phase HPLC methodology
Isocratic and gradient HPLC elution
UV/visible, diode array, CAD Corona and MS detection (HPLC)
Purity determination methods developed for specific compounds
Rapid preparative HPLC purification of multiple compounds
Targeted preparative HPLC purification/separation of specific molecules
NMR spectroscopy
A fully automated high resolution 300MHz provides the following capabilities Open access 1D spectra for 1H, 13C, nuclei
Open access 2D spectra such as COSY, HETCOR, NOESY
On request specialist experiments such as 1D nOe difference,
Structural confirmation/elucidation
Purity determination
Mass spectrometry
The analytical labs are equipped with the Waters/Micromass mass spectrometers equipped with ESI source. These can be coupled to HPLC in order to identify impurities and degradation components.
Method development
Typical method development areas includes:
Purity and identity testing of products from discovery and development
Purity and identity testing of raw materials, intermediates and final products
Methods in support of synthetic organic reaction monitoring
Preparative HPLC purification
Wet chemical techniques
The analytical team can provide water content analysis by coulometric Karl-Fischer titration.
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